Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH)
نویسندگان
چکیده
منابع مشابه
Bcl6 mediates the development of T follicular helper cells.
A fundamental function of CD4+ helper T (T(H)) cells is the regulation of B cell-mediated humoral immunity. Development of T follicular helper (T(FH)) cells that provide help to B cells is mediated by the cytokines interleukin-6 and interleukin-21 but is independent of TH1, TH2, and TH17 effector cell lineages. Here, we characterize the function of Bcl6, a transcription factor selectively expre...
متن کاملThe transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6
Follicular T helper (Tfh) cells are key regulators of the germinal center reaction and long-term humoral immunity. Tfh cell differentiation requires the sustained expression of the transcriptional repressor Bcl6; however, its regulation in CD4(+)T cells is incompletely understood. Here, we report that the transcriptional coactivator Bob1, encoded by thePou2af1gene, promotes Bcl6 expression and ...
متن کاملRepression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells.
Follicular helper T cells (TFHs) are a key component of adaptive immune responses as they help antibody production by B cells. Differentiation and function of TFH cells are controlled by the master gene BCL6, but it is largely unclear how this transcription repressor specifies the TFH program. Here we asked whether BCL6 controlled helper function through down-regulation of specific microRNAs (m...
متن کاملImpaired Function of CD4+ T Follicular Helper (Tfh) Cells Associated with Hepatocellular Carcinoma Progression
BACKGROUND AND AIMS CD4+ T follicular helper (Tfh) cells, a new subset of immune cells, have been demonstrated to be involved in the development and prognosis of tumors. However, their functional role in human hepatocellular carcinoma (HCC) is relatively unknown, and the detailed mechanisms in HCC development remain to be described. METHODS A total of 85 HCC patients with hepatitis B virus (H...
متن کاملIn vivo regulation of Bcl6 and T follicular helper cell development.
Follicular helper T (T(FH)) cells, defined by expression of the surface markers CXCR5 and programmed death receptor-1 (PD-1) and synthesis of IL-21, require upregulation of the transcriptional repressor Bcl6 for their development and function in B cell maturation in germinal centers. We have explored the role of B cells and the cytokines IL-6 and IL-21 in the in vivo regulation of Bcl6 expressi...
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ژورنال
عنوان ژورنال: Trends in Immunology
سال: 2021
ISSN: 1471-4906
DOI: 10.1016/j.it.2021.02.002